-
Therapeutic Category
- LOCAL ANAESTHEITICS
- Anaesthetics
- Pharmaceutical Form : Gel
- Composition : Each gram contains 50 mg Lidocaine.
- Active Substance : Lidocaine
PHARMACOLOGICAL PROPERTIES:
Pharmacodynamic properties:
Lidocaine is an amide local anesthetic agent with a fast onset, blocking peripheral nervous conduction.
Pharmacokinetic properties:
Lidocaine is readily absorbed from mucosal surfaces, especially if inflamed. The plasma half-life is about 10 minutes following an intravenous dose, with an elimination half-life around 2 hours.
Lidocaine will reach all tissues including transplacental transfer.
THERAPEUTIC INDICATIONS:
- Local anesthesia for topical use including, surface anesthesia of gums in dentistry.
- Pain relief from anal fissures, pruritis ani, pruritis vulvae, haemorrhoids, herpes zoster and herpes labialis.
- For symptomatic relief of sore nipples in nursing mothers.
- As a lubricant in proctoscopy and cytoscopy.
POSOLOGY AND METHOD OF ADMINISTRATION
Cutaneous/oromucosal use.
Adult, elderly and children:
- Dentistry: Apply to dry gum and rub gently.
- Nursing mothers: Apply to the nipples using a small piece of gauze, wash off immediately before next feed.
- All other indications: Apply 1 to 2 ml when required.
Avoid long-term use which may lead to hypersensitivity.
CONTRAINDICATIONS:
Known sensitivity to lidocaine or other amide local anesthetics.
SPECIAL WARNINGS AND PRECAUTIONS FOR USE
THIS PRODUCT is not intended for use with aseptic techniques.
INTERACTIONS:
Although absorption of lidocaine from mucous membranes is marked, doses for topical anesthesia are low. However, the following interactions should be considered:
Cimetidine and propranolol may inhibit the metabolism and thus enhance lidocaine toxicity.
PREGNANCY AND LACTATION:
In common with other drugs, THIS PRODUCT should not be used in early pregnancy unless the benefits outweigh the potential risks.
EFFECTS ON ABILITY TO DRIVE AND USE MACHINES:
No or negligible influence. Lidocaine administered parenterally may cause CNS stimulation, dizziness, nausea followed by depression and drowsiness.
UNDESIRABLE EFFECTS:
Allergic effects are uncommon to lidocaine but have been recorded, usually following parenteral administration. Hypersensitivity may occur in long-term topical use.
OVERDOSAGE:
Unlikely from topical use even if whole contents of a tube (1500 mg lidocaine) has been ingested – oral bioavailability is low but hypotension and heart block may occur. Employ appropriate resuscitation.
PACKAGING:
30 g tube.
STORAGE CONDITIONS:
Store in a dry place below 25° C