- NONSTEROIDAL ANTI-INFLAMMATORY DRUGS
- Pharmaceutical Form : S.R. Coated Tablet
- Composition : Ketoprofen 200 mg / S. R . Ctd. Tab
- Active Substance : Ketoprofen
Ketoprofen a propionic acid derivative , is non steroidal anti-inflammatory drug with analgesic , anti
pyretic and anti-inflammatory properties .
Ketoprofen acts by inhibiting the cyclo – oxygenizes which are involved in the biosynthesis of
Ketophen tablets are designed to resist dissolution in the low PH of gastric fluid but release drug at a
controlled rate in the higher PH of the small intestine.
Ketophen is used in the management of :
-Musculoskeletal and joint disorders such as : ankylosing spondylitis , osteoarthritis , and rheumatoid
-Peri-articular disorders such as : bursitis and tendinitis.
– painful and inflammatory conditions such as : acute gout or soft-tissue disorders .
-Patients sensitive to aspirin or other-nonsteroidal anti-inflammatory agents.
Side effects :
the commonest side effects are generally gastro-intestinal disturbances :
( Nausea , vomiting, ulceration , bleeding , diarrhoea ).
Other side effects : headache , dizziness , nervousness , blurred vision , tinnitus , acute interstitial
nephritis, pancreatitis , skin rashes , broncho constriction , renal failure ,and rarely neutropenia .
-Ketophen should be used with caution in patients with haemorrhagic disorders , asthma , hypertension
and impaired renal , hepatic or cardiac function .
– should be used with caution in elderly patients.
-Physicians should follow chronically treated patients for the signs and symptoms of ulceration and
bleeding and should inform them about the importance of this follow-up.
Drug interactions :
-Concurrent use of Aspirin and Ketoprofen is not recommended.
-Ketoprofen increases the plasma concentrations of lithium, and methorexate .
-The risk of gastro-intestinal bleeding and ulceration associated with Ketoprofen increases when used
with corticosteroids .
– Concurrent therapy with Ketoprofen and warfarin requires close monitoring of patients on both drugs.
-The risk of nephrotoxicity may be increased if Ketoprofen given with diuretics .
Dosage and Administration:
-The usual daily dose is 200 mg with food .
– Doses higher than 200 mg/day are not recommended.
Storage conditions : store up to 30°C
packing : box of 20 S.R tablet